Vascular Endothelial Growth Factor Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
نویسنده
چکیده
Background: Among the molecular events involved in carcinogenesis, neovascularization or angiogenesis is considered to be crucial for tumor growth and progression. VEGF is an angiogenic cytokine involved in endothelial cell proliferation, migration and differentiation. Aim: The purpose of this study was to investigate the immunohistochemical expression of VEGF in normal oral mucosa (NOM), epithelial dysplasia and oral squamous cell carcinoma (OSCC) and to correlate this expression with histologic features of tumor progression. Materials and methods: In this retrospective study, we examined the immunohistochemical expression of VEGF in 46 oral mucosal biopsy samples which consisted of 5 normal oral mucosal specimens, 17 specimens with varying histologic degrees of epithelial dysplasia and 24 invasive OSCC specimens with varying grades of tumor differentiation. Results: Statistical analysis indicated an upregulation of VEGF during the transition from NOM through epithelial dysplasia to between various grades of dysplasia. An increased and intense expression of VEGF was observed in different histologic grades of squamous cell carcinoma with well differentiated OSCC showing the lowest mean VEGF percentage and intensity scores and poorly differentiated OSCC, the highest. Conclusion: Our results suggest that VEGF is present in elevated levels in dysplasias and OSCCs when compared with normal oral mucosal specimens. Increased levels of this angiogenic factor could enhance tumor growth by promoting neovascularization.
منابع مشابه
Vascular endothelial growth factor expression and vascular densi-ty in oral squamous cell carcinoma (OSCC): A study on clinical and histopathologic significance
Background: New blood vessels formation is a critical step in tumor progression. Vascular density affects the clinical outcome and prognosis of malignant tumors. The aim of this study was to investigate the relation between the Vascular Endothelial Growth Factor (VEGF) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (OSCC).  ...
متن کاملVascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients
Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was pe...
متن کاملComparing Immunohistochemical Expression of Podoplanin between Oral Squamous Cell Carcinoma and Normal Oral Mucosa
Background and purpose: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. Podoplanin is a mucin-like integral membrane glycoprotein that is expressed in the lymphatic endothelial cells but not in the blood vascular endothelial cells. The aim of the present study was to investigate the immunohistochemical expression of podoplanin and evaluating lymphangiogenesis i...
متن کاملAngiogenesis and Tumor-Associated Macrophages in Different Grades of Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Epithelial Dysplasia via Immunohistochemical Assessment of Expression of CD34 and CD68 Markers
Background:Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity, which is highly invasive. Verrucous carcinoma (VC) is the low-grade form of SCC. Epithelial dysplasia (ED) also has a malignant potential. This immunohistochemical (IHC) study aimed to assess angiogenesis and the presence of tumor-associated macrophages (TAMs) in SCC, VC and ED to determi...
متن کاملCorrelation of vascularization and inflammation with severity of oral leukoplakia
Background & objective: Changes in submucosal vascularization and inflammation, determined by immunohistochemistry staining, were shown to be correlated with the development of dysplasia and invasiveness of epithelial cells in premalignant and malignant lesions. This study evaluated changes in sections routinely stained with Hematoxylin and Eosin (H&E;) in orde...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013